
Why you are doing something matters as much as What you are doing. You can be doing an important work, but if you cannot assign the work to purpose, you do not feel significance. This is why med school, for example, is not for everyone.
One the other end, you can be doing the most mundane task, like washing dishes or helping your child with homework. But if you understand the purpose and importance behind it, you have found significance in your work. Significance starts on the inside.

